Triple Negative Breast CA

Triple Negative Breast Cancer (TNBC) – Epidemiology

 

  • All TNBC share the lack of ER, PR and HER2, ERBB2 expression2
  • TNBC patients are typically young (<40 years old), African American and have shorter progression free survival (PFS) and overall survival (OS) in comparison to non-TNBC cancer2
  • A woman living in the U.S. has a 12.4% chance (1 in 8) lifetime risk of being diagnosed with breast cancer1
  • A majority of basal like cancers are also triple-negative breast cancers, and the majority of triple negative breast cancers (about 80%) are also basal like breast cancers3
  • Triple negative and basal-like tumors make up about 15-20% of all invasive breast cancers, and are often associated with a high histologic grade3
  • Black and Hispanic women have higher rates of both triple negative and basal like breast cancer in comparison to young women of any other racial or ethnic group3
  • The shape of the survival curve for patients with triple negative breast cancer in comparison to other types of breast cancer patients includes a sharp decrease in survival during the first 2-5 years post diagnosis3
  • At the morphological level, TNBC and basal-like breast cancer (BLBC) are similar in terms of larger tumor size, higher grade, presence of geographic necrosis, enhanced invasive potential and stromal lymphocytic infiltration2

 

 

References:

  1. American Cancer Society. Breast Cancer Facts & Figures 2017-2018. Atlanta: American Cancer Society, Inc. 2017.
  2. Sporikova Z, Koudelakova V, Trojanec R, Hajduch M, Genetic Markers inTriple-Negative Breast Cancer, Clinical Breast Cancer (2018), doi: 10.1016/j.clbc.2018.07.023
  3. Foulkes WD et al. Triple-Negative Breast Cancer. NEJM. 2010;363:1938-1948