NSCLC Non-Small Cell Lung Cancer (NSCLC) Epidemiology Lung cancer is the leading cause of cancer-related death in the United States1,2, representing an estimated 23.5% of all cancer deaths for 20192 Estimated new cases of lung and bronchus cancer (non-small cell and small cell combined) in 2019 = 228,150, a projected 12.9% of all new cancer cases2,3 Per data from 2012-2016, incidence of lung and bronchus cancer cases per 100,000 persons was slightly higher in males (54.9) than females (41.9)2 About 80%-85% of these cancers are NSCLC4, which encompass various subtypes4: Adenocarcinoma (~40%) Squamous cell (epidermoid) carcinoma (~25%-30%) Large cell (undifferentiated) carcinoma (~10%-15%) “Other” subtypes, including adenosquamous carcinoma and sarcomatoid carcinoma (uncommon) Diagnosis of lung and bronchus cancer typically spans from the 4th to 9th decades of life, but is most frequently diagnosed among those aged 65-742 The lifetime risk of developing lung and bronchus cancer is 6.3% (men and women) based on 2014-2016 data2, with the primary risk factor of tobacco smoking based on pack-year history1 5-year relative survival rates for NSCLC are highest with localized disease, but only 23% with all SEER stages combined5 Non-Small Cell Lung Cancer (NSCLC). NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Version 5.2019 – June 7, 2019. Available at: https://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf. Accessed: June 30, 2019. National Cancer Institute. Surveillance, Epidemiology, and End Results Program. Cancer Stat Facts: Lung and Bronchus Cancer. Available at: https://seer.cancer.gov/statfacts/html/lungb.html. Accessed: June 30, 2019. National Cancer Institute. Non-Small Cell Lung Cancer Treatment (PDQ®) – Health Professional Version. Available at: https://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq/#_4. Accessed: June 30, 2019. American Cancer Society. About non-small cell lung cancer. Available at: https://www.cancer.org/cancer/non-small-cell-lung-cancer/about/what-is-non-small-cell-lung-cancer.html. Accessed: June 30, 2019. American Cancer Society. Non-Small Cell Lung Cancer Survival Rates. Available at: https://www.cancer.org/cancer/non-small-cell-lung-cancer/detection-diagnosis-staging/survival-rates.html. Accessed: June 30, 2019.