Non-Small Cell Lung Cancer (NSCLC) Epidemiology

  • Lung cancer is the leading cause of cancer-related death in the United States1,2, representing an estimated 23.5% of all cancer deaths for 20192
  • Estimated new cases of lung and bronchus cancer (non-small cell and small cell combined) in 2019 = 228,150, a projected 12.9% of all new cancer cases2,3
  • Per data from 2012-2016, incidence of lung and bronchus cancer cases per 100,000 persons was slightly higher in males (54.9) than females (41.9)2
  • About 80%-85% of these cancers are NSCLC4, which encompass various subtypes4:
    • Adenocarcinoma (~40%)
    • Squamous cell (epidermoid) carcinoma (~25%-30%)
    • Large cell (undifferentiated) carcinoma (~10%-15%)
    • “Other” subtypes, including adenosquamous carcinoma and sarcomatoid carcinoma (uncommon)
  • Diagnosis of lung and bronchus cancer typically spans from the 4th to 9th decades of life, but is most frequently diagnosed among those aged 65-742
  • The lifetime risk of developing lung and bronchus cancer is 6.3% (men and women) based on 2014-2016 data2, with the primary risk factor of tobacco smoking based on pack-year history1
  • 5-year relative survival rates for NSCLC are highest with localized disease, but only 23% with all SEER stages combined5

  1. Non-Small Cell Lung Cancer (NSCLC). NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines).  Version 5.2019 – June 7, 2019.  Available at:  https://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf.  Accessed: June 30, 2019.
  2. National Cancer Institute. Surveillance, Epidemiology, and End Results Program.  Cancer Stat Facts: Lung and Bronchus Cancer.  Available at: https://seer.cancer.gov/statfacts/html/lungb.html.  Accessed: June 30, 2019.
  3. National Cancer Institute. Non-Small Cell Lung Cancer Treatment (PDQ®) – Health Professional Version. Available at:  https://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq/#_4.  Accessed: June 30, 2019.
  4. American Cancer Society. About non-small cell lung cancer. Available at: https://www.cancer.org/cancer/non-small-cell-lung-cancer/about/what-is-non-small-cell-lung-cancer.html. Accessed: June 30, 2019.
  5. American Cancer Society. Non-Small Cell Lung Cancer Survival Rates. Available at: https://www.cancer.org/cancer/non-small-cell-lung-cancer/detection-diagnosis-staging/survival-rates.html. Accessed: June 30, 2019.