Head and Neck Head and Neck Cancer In the year 2000, head and neck cancer was the 8th leading cause of cancer death worldwide1 Head and neck cancers account for an estimated 4% of all cancers in the United States (US)2, with oral cavity and pharynx cancer representing 3% of all new US cancer cases3 Head and neck cancers are more than two times as common in men than women 1,2 Head and neck cancers are diagnosed more often in people over the age of 50 years in comparison to younger people2 Based on 2012-2016 cases and deaths, the number of new cases of oral cavity and pharynx cancer was 11.3 per 100,000 men and women annually3 Oral cancer is more common among those with a history of tobacco use, heavy alcohol use and human papillomavirus (HPV) infection3 Incidence of oral and oropharyngeal cancers is comparable among black and white ethnicities in the US4 Estimated age-standardized incidence/mortality rates for cancers of the lip and oral cavity in males and females was 7.0/2.3 and 2.6/0.6 per 100,000 people annually, with higher rates noted in more developed regions5 Other cancers of the oral cavity and oropharynx do not have available survival rates by stage, but do have overall relative 5-year survival rates3 References: Ragin CCR, Modugno F, Gollin SM. The Epidemiology and risk factors of head and neck cancer: a focus on human papillomavirus. J Dent Res. 2007;86(2):104-114. National Institute of National Cancer Institute. Head and Neck. Available at: https://www.cancer.gov/types/head-and-neck/head-neck-fact-sheet. Reviewed: March 2017. Accessed June 30, 2019. National Institute of National Cancer Institute. Oral Cavity and Pharynx Cancers. Available at: https://seer.cancer.gov/statfacts/html/oralcav.html. Accessed June 2019. American Cancer Society. Key Statistics for Oral Cavity and Oropharyngeal Cancers. Last Revised: January, 2019. Accessed: June 30, 2019. https://www.cancer.org/cancer/oral-cavity-and-oropharyngeal-cancer/about/key-statistics.html Gupta B, Johnson NW, Kumar N. Global epidemiology of head and neck cancers: A continuing challenge. Oncology. 2016;91(1):13-23.