Triple Negative Breast CA

Triple Negative Breast Cancer (TNBC) – Epidemiology


  • All TNBC share the lack of ER, PR and HER2, ERBB2 expression2
  • TNBC patients are typically young (<40 years old), African American and have shorter progression free survival (PFS) and overall survival (OS) in comparison to non-TNBC cancer2
  • A woman living in the U.S. has a 12.4% chance (1 in 8) lifetime risk of being diagnosed with breast cancer1
  • A majority of basal like cancers are also triple-negative breast cancers, and the majority of triple negative breast cancers (about 80%) are also basal like breast cancers3
  • Triple negative and basal-like tumors make up about 15-20% of all invasive breast cancers, and are often associated with a high histologic grade3
  • Black and Hispanic women have higher rates of both triple negative and basal like breast cancer in comparison to young women of any other racial or ethnic group3
  • The shape of the survival curve for patients with triple negative breast cancer in comparison to other types of breast cancer patients includes a sharp decrease in survival during the first 2-5 years post diagnosis3
  • At the morphological level, TNBC and basal-like breast cancer (BLBC) are similar in terms of larger tumor size, higher grade, presence of geographic necrosis, enhanced invasive potential and stromal lymphocytic infiltration2




  1. American Cancer Society. Breast Cancer Facts & Figures 2017-2018. Atlanta: American Cancer Society, Inc. 2017.
  2. Sporikova Z, Koudelakova V, Trojanec R, Hajduch M, Genetic Markers inTriple-Negative Breast Cancer, Clinical Breast Cancer (2018), doi: 10.1016/j.clbc.2018.07.023
  3. Foulkes WD et al. Triple-Negative Breast Cancer. NEJM. 2010;363:1938-1948