Breast CA Breast Cancer Breast cancer is the most frequently diagnosed cancer worldwide,1 with estimated new female cases within the United States in 2019 = 268,600 (a projected 15.2% of all new cancer cases2,3), and a lifetime risk of disease development of about 1 in 84,5 Breast cancer is also the leading cause of cancer-related death in women,1 with estimated American female deaths in 2019 = 41,670, a projected 6.9% of all cancer deaths2,3,5 Statistics for male breast cancer within the United States are lower, with estimated incidence = 2,6703,4 and estimated deaths = 500 in 20193, and a lifetime risk of developing breast cancer of about 1 in 8834 Per data from 2011-2015, incidence of female breast cancer cases per 100,000 persons was greatest in non-Hispanic white (130.1) and non-Hispanic black (126.5)3 ethnicities Overall mortality from breast cancer has been decreasing since 1991, suggesting benefit from early detection and increasingly effective treatment1 Classification of breast cancer is based on molecular profiling results into the following categories6: Hormone receptor (estrogen receptor – ER or progesterone receptor – PR) positive Human epidermal growth factor type 2 receptor (HER2/neu) positive Triple negative (ER, PR, and HER2/neu negative) Diagnosis of breast cancer (in females) typically spans from the 3rd to 9th decades of life, but is most frequently diagnosed among those aged 55-642 The probability of females developing and dying from breast cancer increases with age, with greatest probability in persons ≥70-years-old3 5-year relative survival rates for female breast cancer are highest with localized disease at diagnosis, but only 27% in distant disease2,3 Breast Cancer. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Version 2.2019 – July 2, 2019. Available at: https://www.nccn.org/professionals/physician_gls/pdf/breast.pdf. Accessed: August 23, 2019. National Cancer Institute. Surveillance, Epidemiology, and End Results Program. Cancer Stat Facts: Female Breast Cancer. Available at https://seer.cancer.gov/statfacts/html/breast.html. Accessed: August 23, 2019. American Cancer Society. Cancer Statistics Center. Breast at a Glance. Available at: https://cancerstatisticscenter.cancer.org/#!/cancer-site/Breast. Accessed: August 23, 2019. BreastCancer.org. U.S. Breast Cancer Statistics. Available at: https://www.breastcancer.org/symptoms/understand_bc/statistics. Accessed: August 23, 2019. American Cancer Society. About Breast Cancer. Available at: https://www.cancer.org/content/dam/CRC/PDF/Public/8577.00.pdf. Accessed: August 30, 2019. National Cancer Institute. Breast Cancer Treatment (PDQ®) – Health Professional Version. Available at: https://www.cancer.gov/types/breast/hp/breast-treatment-pdq. Accessed: August 30, 2019.