Breast CA

Breast Cancer

  • Breast cancer is the most frequently diagnosed cancer worldwide,1 with estimated new female cases within the United States in 2019 = 268,600 (a projected 15.2% of all new cancer cases2,3), and a lifetime risk of disease development of about 1 in 84,5
  • Breast cancer is also the leading cause of cancer-related death in women,1 with estimated American female deaths in 2019 = 41,670, a projected 6.9% of all cancer deaths2,3,5
  • Statistics for male breast cancer within the United States are lower, with estimated incidence = 2,6703,4 and estimated deaths = 500 in 20193, and a lifetime risk of developing breast cancer of about 1 in 8834
  • Per data from 2011-2015, incidence of female breast cancer cases per 100,000 persons was greatest in non-Hispanic white (130.1) and non-Hispanic black (126.5)3 ethnicities
  • Overall mortality from breast cancer has been decreasing since 1991, suggesting benefit from early detection and increasingly effective treatment1
  • Classification of breast cancer is based on molecular profiling results into the following categories6:
    • Hormone receptor (estrogen receptor – ER or progesterone receptor – PR) positive
    • Human epidermal growth factor type 2 receptor (HER2/neu) positive
    • Triple negative (ER, PR, and HER2/neu negative)
  • Diagnosis of breast cancer (in females) typically spans from the 3rd to 9th decades of life, but is most frequently diagnosed among those aged 55-642
  • The probability of females developing and dying from breast cancer increases with age, with greatest probability in persons ≥70-years-old3
  • 5-year relative survival rates for female breast cancer are highest with localized disease at diagnosis, but only 27% in distant disease2,3

 

  1. Breast Cancer. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Version 2.2019 – July 2, 2019. Available at:  https://www.nccn.org/professionals/physician_gls/pdf/breast.pdf. Accessed: August 23, 2019.
  2. National Cancer Institute. Surveillance, Epidemiology, and End Results Program. Cancer Stat Facts: Female Breast Cancer.  Available at https://seer.cancer.gov/statfacts/html/breast.html. Accessed: August 23, 2019.
  3. American Cancer Society. Cancer Statistics Center. Breast at a Glance. Available at: https://cancerstatisticscenter.cancer.org/#!/cancer-site/Breast. Accessed: August 23, 2019.
  4. BreastCancer.org. U.S. Breast Cancer Statistics. Available at: https://www.breastcancer.org/symptoms/understand_bc/statistics. Accessed: August 23, 2019.
  5. American Cancer Society. About Breast Cancer. Available at: https://www.cancer.org/content/dam/CRC/PDF/Public/8577.00.pdf. Accessed: August 30, 2019.
  6. National Cancer Institute. Breast Cancer Treatment (PDQ®) – Health Professional Version. Available at:  https://www.cancer.gov/types/breast/hp/breast-treatment-pdq. Accessed: August 30, 2019.