AML

AML Epidemiology

  • Estimated new cases of AML in 2019 = 21,450, projected to represent 1.2% of all new cancer cases1,3
    • Based on data from 2012 to 2016, the number of new AML cases was 4.3 per 100,000 men and women1
    • Approximately 0.5% of men and women will be diagnosed with AML at some point during their lifetime1
  • AML is the most common form of acute leukemia among adults2-5
  • AML is more common among men compared with women1,3,4
  • AML is diagnosed more frequently in people 65-74 years of age1
  • From 2009 to 2015, the percent of patients with AML surviving 5 years was 28.3%1
  • Estimated deaths due to AML in 2019 = 10,920, which was projected to represent 1.8% of all cancer deaths1,3
    • Percent of AML deaths is highest among older adults aged 75-84 years1
    • Median age at death = 721
    • AML accounts for the largest number of annual deaths yearly from leukemias in the U.S.2
  • An estimated 60%-70% of adults with AML can expect to attain CR status after appropriate induction therapy3
  • Remission rates for adults with AML are inversely related to age, and expected remission rate of > 65% for patients < 60 years3
  • Currently, there is no standard regimen for the treatment of patients with relapsed AML3
  • APL (Acute Promyelocytic Leukemia) is an aggressive subtype of AML2
    • Approximately 10% of AML cases are APL2
    • Median age at diagnosis of APL = 44 years2

Sources and Additional Reading

  1. National Cancer Institute. Surveillance, Epidemiology, and End Results Program. Cancer Stat Facts: Leukemia – Acute Myeloid Leukemia (AML). Available: https://seer.cancer.gov/statfacts/html/amyl.html. Accessed: June, 2019
  2. Acute Myeloid Leukemia (AML). NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Version 3.2019 – May 7, 2019. Available: https://www.nccn.org/professionals/physician_gls/pdf/aml.pdf Accessed: June 19, 2019
  3. National Cancer Institute. Adult Acute Myeloid Leukemia Treatment (PDQ®) – Health Professional Version. Available: https://www.cancer.gov/types/leukemia/hp/adult-aml-treatment-pdq Accessed: June 30, 2019
  4. American Cancer Society. Key Statistics for Acute Myeloid Leukemia. Available: https://www.cancer.org/cancer/acute-myeloid-leukemia/about/key-statistics.html Accessed: June 30, 2019
  5. De Kouchkovsky I, Abdul-Hay M. Acute myeloid leukemia: a comprehensive review and 2016 update. Blood Cancer J. 2016; 6(7): e44.
  6. Sacks NC, Cyr PL, et al. Burden of Acute Myeloid Leukemia Among Older, Newly Diagnosed Patients: Retrospective Analysis of Data From the 2010–2012 Medicare Limited Data Set. Clin Ther. 2018;40(5):692-703.e2.